Modulation of endogenous hormone action by recombinant human tumor necrosis factor.
نویسندگان
چکیده
منابع مشابه
Mediation of Anorexia by Human Recombinant Tumor Necrosis Factor through a Peripheral Action in the Rat1
Human recombinant tumor necrosis factor (TNF) produces significant anorexia in the rat which persists for up to 24 h after a single dose (5 Mg/325g rat). Dose-response studies indicate similar potencies for TNF following central or peripheral administration. Brain I2SI-TNFlevels were more than 100-fold greater after intracerebroventricular than i.v. injec tion, whereas blood levels of radioacti...
متن کاملMediation of anorexia by human recombinant tumor necrosis factor through a peripheral action in the rat.
Human recombinant tumor necrosis factor (TNF) produces significant anorexia in the rat which persists for up to 24 h after a single dose (5 micrograms/325 g rat). Dose-response studies indicate similar potencies for TNF following central or peripheral administration. Brain 125I-TNF levels were more than 100-fold greater after intracerebroventricular than i.v. injection, whereas blood levels of ...
متن کاملInduction of synthesis of tumor necrosis factor in human and murine cell lines by exogenous recombinant human tumor necrosis factor.
Treatment of sensitive human myosarcoma cells (KYM-S) with exogenous tumor necrosis factor (r-TNF) resulted in the production of TNF by the cells. The newly synthesized cellular TNF was identified immunologically on Western blots and as a single 1.8-kilobase band on Northern blots. TNF synthesis began within 2 h of administration of the exogenous TNF in a dose-dependent manner. r-TNF also induc...
متن کاملCachectic effects of recombinant human tumor necrosis factor in rats.
Treatment of rats with either intermittent bolus i.v. injections or continuous i.v. infusions of the same sublethal daily dose of tumor necrosis factor (TNF) results in decreased food intake and decreased nitrogen balance compared to saline-treated control rats. After 4 days of treatment, rats treated with intermittent bolus doses of TNF develop tolerance to the nutritional effects and consume ...
متن کاملImmunomodulatory properties of recombinant murine and human tumor necrosis factor.
Tumor necrosis factor has traditionally been thought to have direct cytostatic and cytotoxic properties with little or no direct immunomodulatory activity. We report here that tumor necrosis factor is able to activate macrophages both in vitro and in vivo and can increase a mixed lymphocyte response and act as an adjuvant for both T- and B-cells in vivo. Adjuvant activity in T-cells occurred in...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1987
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.84.23.8619